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Kun-Hung Chen Selected Research

1- (2,4- dichlorophenyl)- N- (piperidin- 1- yl)- 4- ((pyrrolidine- 1- sulfonamido)methyl)- 5- (5- ((4- (trifluoromethyl)phenyl)ethynyl)thiophene- 2- yl)- 1H- pyrazole- 3- carboxamide

12/2013Discovery of 1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a novel peripherally restricted cannabinoid-1 receptor antagonist with significant weight-loss efficacy in diet-induced obese mice.

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Kun-Hung Chen Research Topics

Disease

2Rheumatoid Arthritis
06/2020 - 12/2004
2Neoplasms (Cancer)
01/2019 - 09/2014
1Pain (Aches)
06/2020
1Brain Diseases (Brain Disorder)
01/2019
1Glioblastoma (Glioblastoma Multiforme)
01/2019
1Reperfusion Injury
10/2016
1Acquired Hyperostosis Syndrome (SAPHO Syndrome)
07/2015
1Weight Loss (Weight Reduction)
12/2013
1Ankylosing Spondylitis
12/2010

Drug/Important Bio-Agent (IBA)

2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
12/2010 - 12/2004
1Tumor Necrosis Factor InhibitorsIBA
06/2020
1Antirheumatic Agents (DMARD)IBA
06/2020
1C-Reactive ProteinIBA
06/2020
1liposomal doxorubicin (Doxil)FDA Link
01/2019
1Liposomes (Liposome)IBA
01/2019
1Polystyrenes (Polystyrene)IBA
10/2016
1Interleukin-1 (Interleukin 1)IBA
07/2015
1Peptides (Polypeptides)IBA
09/2014
11- (2,4- dichlorophenyl)- N- (piperidin- 1- yl)- 4- ((pyrrolidine- 1- sulfonamido)methyl)- 5- (5- ((4- (trifluoromethyl)phenyl)ethynyl)thiophene- 2- yl)- 1H- pyrazole- 3- carboxamideIBA
12/2013
1Etanercept (Enbrel)FDA Link
12/2010
1NF-kappa B (NF-kB)IBA
12/2004

Therapy/Procedure

2Therapeutics
06/2020 - 01/2019
1Drug Therapy (Chemotherapy)
01/2019